# 常见代谢通路

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2F9SdtqRwVbUuuCunHJZp7%2Fimage.png?alt=media&#x26;token=0ef3cfea-dbfc-4c25-b829-c62b631eebe6" alt=""><figcaption><p>Acetyl-CoA metabolism in cancer. 2023</p></figcaption></figure>

## 糖酵解（Glycolysis；EMP途径）

## 三羧酸循环（TCA cycle）

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2FcY7xczGghgWLUk3qqcAv%2Fimage.png?alt=media&#x26;token=c447b7f2-e559-40e6-b6ad-b25dc173c565" alt="" width="563"><figcaption><p>Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism</p></figcaption></figure>

## 氧化磷酸化（OXPHOS）

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2Fy75SK4a6ks5C7eIYjPDU%2Fimage.png?alt=media&#x26;token=8a20fd33-427f-4908-9550-4070b5a6e365" alt="" width="563"><figcaption><p>Mitochondrial complex I promotes kidney cancer metastasis</p></figcaption></figure>

## 谷氨酰胺代谢

### 1、氧化代谢（Oxidative metabolism）

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2Fj74YIIALJ5ipfIei1ENd%2Fimage.png?alt=media&#x26;token=6430b8d3-49ee-4150-bc6a-2ab52673e24f" alt="" width="563"><figcaption><p>Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism. FigS5G</p></figcaption></figure>

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2FVw3YV2WAzxrgCo7asqJ8%2Fimage.png?alt=media&#x26;token=5b2f39c7-7196-4332-9fcd-5ebb2becc928" alt="" width="563"><figcaption><p>Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism</p></figcaption></figure>

### 2、还原羧化（reductive carboxylation, **RC**）

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2F8JdUPITXb5gQv4OntnDd%2Fimage.png?alt=media&#x26;token=8bc4c197-b029-4a6e-ab98-3edfa4835d95" alt="" width="563"><figcaption><p>Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism. FigS5I</p></figcaption></figure>

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2FkF76f3YlSSqFWDAcEQN4%2Fimage.png?alt=media&#x26;token=736ae36d-89d0-414c-9bcd-5772a2a070a7" alt="" width="563"><figcaption><p>Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism</p></figcaption></figure>

### 3、总和

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2Fiwpcatdqm1E1Ww71lEs4%2Fimage.png?alt=media&#x26;token=e8fe3a63-dcf5-4be2-b031-019a304f7e6b" alt="" width="375"><figcaption><p>Glutamine的氧化和还原代谢通路</p></figcaption></figure>

<figure><img src="https://3583750438-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FrNJkPTdpyVMk09ldgu9A%2Fuploads%2FA2qm0rd5O1DaEnHsyxpc%2Fimage.png?alt=media&#x26;token=e6d6c475-f7bd-474a-b2d0-32c58f49799c" alt=""><figcaption><p>Cellular ATP demand creates metabolically distinct subpopulations of mitochondria</p></figcaption></figure>

## 磷酸戊糖途径（Pentose Phosphate Pathway，PPP）

## 糖异生